1. Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.
- Author
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Wen HM, Zhang YW, Feng FJ, Huang GB, Lv YH, Zhang ZY, and Ding LJ
- Subjects
- Animals, Molecular Structure, Ergosterol pharmacology, Ergosterol chemistry, Ergosterol isolation & purification, Humans, Steroids pharmacology, Steroids chemistry, Steroids isolation & purification, Nuclear Magnetic Resonance, Biomolecular, Aspergillus chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Porifera microbiology, Staphylococcus aureus drug effects, Microbial Sensitivity Tests, Marine Biology, Ergosterol analogs & derivatives
- Abstract
Two oxygenated ergostane-type steroids including one new compound, 3 β -hydroxy-5 α ,6 β -methoxyergosta-7,22-dien-15-one ( 1 ) along with a known analogue ergosta-6,22-dien-3 β ,5 α ,8 α -triol ( 2 ) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound 1 exhibited antibacterial activity against Staphylococcus aureus.
- Published
- 2024
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